{"id":54,"date":"2023-03-19T12:54:01","date_gmt":"2023-03-19T11:54:01","guid":{"rendered":"https:\/\/cancerkb.org\/?page_id=54"},"modified":"2023-05-21T20:06:30","modified_gmt":"2023-05-21T18:06:30","slug":"cancer-pathways","status":"publish","type":"page","link":"https:\/\/cancerkb.org\/index.php\/cancer-pathways\/","title":{"rendered":"Cancer Pathways"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"54\" class=\"elementor elementor-54\">\n\t\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-28dab59 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"28dab59\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-75717a9\" data-id=\"75717a9\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-960e7c3 elementor-widget elementor-widget-text-editor\" data-id=\"960e7c3\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.11.3 - 07-03-2023 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#818a91;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#818a91;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<p>Before introducing the major cancer pathways, it&rsquo;s important to look into cancer hallmarks, which were summarised in the image below by Douglas Hanahan and Robert A. Weinberg (publication from 2022). Essentially all the listed pathways below will drive and\/or contribute to one or several cancer hallmarks. In the Treatments tab of this website, treatment strategies that target these pathways\/hallmarks will be discussed in more details<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-d943b10 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"d943b10\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-a0371df\" data-id=\"a0371df\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-45f5403 elementor-widget elementor-widget-image\" data-id=\"45f5403\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.11.3 - 07-03-2023 *\/\n.elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=\".svg\"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block}<\/style>\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/aacr.silverchair-cdn.com\/aacr\/content_public\/journal\/cancerdiscovery\/12\/1\/10.1158_2159-8290.cd-21-1059\/2\/31fig6.jpeg?Expires=1687713671&amp;Signature=niSIuAXqmUunbhYzYCVmAJPDte7fYbCYwnsQaE0mB7VDkUJ13emskagkI28PrgMqI-BhH2n-sGYVu8uRm2br2TQOTKBjYmelLuCjc8TNgFBlNAoBndm~a2f-NlWBOhsiJQ~RAnPMKD-gMF5WRwiZ9vjFvkm75d~9EAdIvtvo5H9-2cMDYJhUwIM5GmduS3CsK7~HxKRXhaVUHXDM57tc~HYzaq3E~qHsVCHRWvKO2ih8yffM2s6e2jvz3nrAiYf8i-f-EfXfbiIt8lEePhv8qyOhuSFP4eactfFaBZBFauuFQ9dhjN5MGQcx~CboJ8sgBN8luK6XPBaQTboVS7pPoQ__&amp;Key-Pair-Id=APKAIE5G5CRDK6RD3PGA\">\n\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/aacr.silverchair-cdn.com\/aacr\/content_public\/journal\/cancerdiscovery\/12\/1\/10.1158_2159-8290.cd-21-1059\/2\/31fig6.jpeg?Expires=1687713671&amp;Signature=niSIuAXqmUunbhYzYCVmAJPDte7fYbCYwnsQaE0mB7VDkUJ13emskagkI28PrgMqI-BhH2n-sGYVu8uRm2br2TQOTKBjYmelLuCjc8TNgFBlNAoBndm~a2f-NlWBOhsiJQ~RAnPMKD-gMF5WRwiZ9vjFvkm75d~9EAdIvtvo5H9-2cMDYJhUwIM5GmduS3CsK7~HxKRXhaVUHXDM57tc~HYzaq3E~qHsVCHRWvKO2ih8yffM2s6e2jvz3nrAiYf8i-f-EfXfbiIt8lEePhv8qyOhuSFP4eactfFaBZBFauuFQ9dhjN5MGQcx~CboJ8sgBN8luK6XPBaQTboVS7pPoQ__&amp;Key-Pair-Id=APKAIE5G5CRDK6RD3PGA\" title=\"\" alt=\"\" loading=\"lazy\">\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d62b18c elementor-widget elementor-widget-text-editor\" data-id=\"d62b18c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Source of image: <em>Cancer Discov<\/em> (2022) 12 (1): 31&ndash;46<\/p><p><a href=\"https:\/\/doi.org\/10.1158\/2159-8290.CD-21-1059\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1158\/2159-8290.CD-21-1059<\/a><\/p><div style=\"text-align: left;\">&nbsp;<\/div>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-9e4858d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"9e4858d\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-a3d28b1\" data-id=\"a3d28b1\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3c85719 elementor-widget elementor-widget-text-editor\" data-id=\"3c85719\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Major cancer pathways can be summarised to this list (https:\/\/doi.org\/10.1016\/j.cell.2018.03.035):<\/p>\n<ol>\n<li>Cell cycle pathway<\/li>\n<li>p53 pathway<\/li>\n<li>MYC pathway<br><\/li>\n<li>PI3K\/Akt pathway<\/li>\n<li>RTK\/RAS pathway<br><\/li>\n<li>NOTCH pathway<br><\/li>\n<li>HIPPO pathway<\/li>\n<li>betaCatenin\/WNT pathway<\/li>\n<li>TGFbeta pathway<\/li>\n<li>NRF2 pathway<\/li>\n<\/ol>\n<p><br><\/p>\n<p><br><\/p>\n<p><br><\/p>\n<p><br><\/p>\n<p>\/<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Before introducing the major cancer pathways, it&#8217;s important to look into cancer hallmarks, which were summarised in the image below by Douglas Hanahan and Robert A. Weinberg (publication from 2022). <a class=\"more-link\" href=\"https:\/\/cancerkb.org\/index.php\/cancer-pathways\/\">Continue Reading &rarr;<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-54","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/cancerkb.org\/index.php\/wp-json\/wp\/v2\/pages\/54","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cancerkb.org\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/cancerkb.org\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/cancerkb.org\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cancerkb.org\/index.php\/wp-json\/wp\/v2\/comments?post=54"}],"version-history":[{"count":22,"href":"https:\/\/cancerkb.org\/index.php\/wp-json\/wp\/v2\/pages\/54\/revisions"}],"predecessor-version":[{"id":147,"href":"https:\/\/cancerkb.org\/index.php\/wp-json\/wp\/v2\/pages\/54\/revisions\/147"}],"wp:attachment":[{"href":"https:\/\/cancerkb.org\/index.php\/wp-json\/wp\/v2\/media?parent=54"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}